A multi-phenotypic cancer model with cell plasticity

The conventional cancer stem cell (CSC) theory indicates a hierarchy of CSCs and non-stem cancer cells (NSCCs), that is, CSCs can differentiate into NSCCs but not vice versa. However, an alternative paradigm of CSC theory with reversible cell plasticity among cancer cells has received much attention very recently. Here we present a generalized multi-phenotypic cancer model by integrating cell plasticity with the conventional hierarchical structure of cancer cells. We prove that under very weak assumption, the nonlinear dynamics of multi-phenotypic proportions in our model has only one stable steady state and no stable limit cycle. This result theoretically explains the phenotypic equilibrium phenomena reported in various cancer cell lines. Furthermore, according to the transient analysis of our model, it is found that cancer cell plasticity plays an essential role in maintaining the phenotypic diversity in cancer especially during the transient dynamics. Two biological examples with experimental data show that the phenotypic conversions from NCSSs to CSCs greatly contribute to the transient growth of CSCs proportion shortly after the drastic reduction of it. In particular, an interesting overshooting phenomenon of CSCs proportion arises in three-phenotypic example. Our work may pave the way for modeling and analyzing the multi-phenotypic cell population dynamics with cell plasticity.Comment: 29 pages,6 figure

Multiple positive solutions for functional dynamic equations on time scales

AbstractIn this paper, we study the following functional dynamic equation on time scales: {[Φ(uΔ(t))]∇+a(t)f(u(t),u(μ(t)))=0,t∈(0,T)T,u(t)=φ(t),t∈[−r,0)T,u(0)−B0(uΔ(0))=0,uΔ(T)=0, where Φ:R→R is an increasing homeomorphism and a positive homomorphism and Φ(0)=0. By using the well-known Leggett–Williams fixed point theorem, existence criteria for multiple positive solutions are established. An example is also given to illustrate the main results

Gamma-Ray Burst Jet Breaks Revisited

Gamma-ray Burst (GRB) collimation has been inferred with the observations of achromatic steepening in GRB light curves, known as jet breaks. Identifying a jet break from a GRB afterglow light curve allows a measurement of the jet opening angle and true energetics of GRBs. In this paper, we re-investigate this problem using a large sample of GRBs that have an optical jet break that is consistent with being achromatic in the X-ray band. Our sample includes 99 GRBs from 1997 February to 2015 March that have optical and, for Swift GRBs, X-ray light curves that are consistent with the jet break interpretation. Out of the 99 GRBs we have studied, 55 GRBs are found to have temporal and spectral behaviors both before and after the break, consistent with the theoretical predictions of the jet break models, respectively. These include 53 long/soft (Type II) and 2 short/hard (Type I) GRBs. Only 1 GRB is classified as the candidate of a jet break with energy injection. Another 41 and 3 GRBs are classified as the candidates with the lower and upper limits of the jet break time, respectively. Most jet breaks occur at 90 ks, with a typical opening angle θj = (2.5 ± 1.0)°. This gives a typical beaming correction factor ${f}_{b}^{-1}\sim 1000$ for Type II GRBs, suggesting an even higher total GRB event rate density in the universe. Both isotropic and jet-corrected energies have a wide span in their distributions: log(Eγ,iso/erg) = 53.11 with σ = 0.84; log(EK,iso/erg) = 54.82 with σ = 0.56; log(Eγ/erg) = 49.54 with σ = 1.29; and log(EK/erg) = 51.33 with σ = 0.58. We also investigate several empirical correlations (Amati, Frail, Ghirlanda, and Liang–Zhang) previously discussed in the literature. We find that in general most of these relations are less tight than before. The existence of early jet breaks and hence small opening angle jets, which were detected in the Swfit era, is most likely the source of scatter. If one limits the sample to jet breaks later than 104 s, the Liang–Zhang relation remains tight and the Ghirlanda relation still exists. These relations are derived from Type II GRBs, and Type I GRBs usually deviate from them

A novel approach to surface defect detection

Defects or flaws in highly loaded structures have a significant impact on the structural integrity. Early inspection of faults can reduce the likelihood of occurrence of potential disasters and limit the damaging effects of destructions. According to our previous work, a novel approach called as Quantitative Detection of Fourier Transform (QDFT) using guided ultrasonic waves is developed in this paper for efficiently detecting defects in pipeline structures. Details of this fast method consist of three steps: First, an in-house finite element code has been developed to calculate reflection coefficients of guided waves travelling in the pipe. Then, based on boundary integral equations and Fourier transform of space-wavenumber domain, theoretical formulations of the quantitative detection are derived as a function of wavenumber using Born approximation. This lays a solid foundation for QDFT method, in which a reference model in a problem with a known defect is utilized to effectively evaluate the unknown defects. Finally, the location and shape of the unknown defect are reconstructed using signal processing for noise removal. Several examples are presented to demonstrate the correctness and efficiency of the proposed methodology. It is concluded that the general two-dimensional surface defects can be detected with high level of accuracy by this fast approach

Circumferential defect detection using ultrasonic guided waves: An efficient quantitative technique for pipeline inspection

Purpose: Quantitatively detecting surface defects in a circular annulus with high levels of accuracy and efficiency has been paid more attention by researchers. The purpose of this study is to investigate the theoretical dispersion equations for circumferential guided waves and then develop an efficient technique for accurate reconstruction of defects in pipes. Design/methodology/approach: The methodology applied to determine defects in pipelines includes four steps. First, the theoretical work is carried out by developing the appropriate dispersion equations for circumferential guided waves in a pipe. In this phase, formulations of strain-displacement relations are derived in a general equidistant surface coordinate. Following that, a semi-analytical finite element method (SAFEM) is applied to solve the dispersion equations. Then, the scattered fields in a circular annulus are calculated using the developed hybrid finite element method and simulation results are in accord with the law of conservation of energy. Finally, the quantitative detection of Fourier transform (QDFT) approach is further enhanced to efficiently reconstruct the defects in the circular annuli, which have been widely used for engineering applications. Findings: Results obtained from four numerical examples of flaw detection problems demonstrate the correctness of the developed QDFT approach in terms of accuracy and efficiency. Reconstruction of circumferential surface defects using the extended QDFT method can be performed without involving the analytical formulations. Therefore, the streamlined process of inspecting surface defects is well established and this leads to the reduced time in practical engineering tests. Originality/value: In this paper, the general dispersion equations for circumferential ultrasonic guided waves have been derived using an equidistant surface coordinate and solved by the SAFEM technique to discover the relationship between wavenumber of a wave and its frequency. To reconstruct defects with high levels of accuracy and efficiency, the QDFT approach has been further enhanced to inspect defects in the annular structure

Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases

The cholinergic anti-inflammatory pathway (CAP) is a neurophysiological mechanism that regulates the immune system. The CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system, including the lungs, spleen, liver, kidneys and gastrointestinal tract. Acetylcholine can interact with α 7 nicotinic acetylcholine receptors (α 7 nAchR) expressed by macrophages and other cytokine producing cells, down-regulate pro-inflammatory cytokine synthesis and prevent tissue damage. Herein is a review of the neurophysiological mechanism in which the CAP regulates inflammatory response, as well as its potential interventional strategy for inflammatory diseases

Positive Solutions for Third-Order p

We study the following third-order p-Laplacian functional dynamic equation on time scales: Φp(uΔ∇(t))∇+a(t)f(u(t),u(μ(t)))=0, t∈0,TT,  u(t)=φ(t),  t∈-r,0T,  uΔ(0)=uΔ∇(T)=0, and u(T)+B0(uΔ(η))=0. By applying the Five-Functional Fixed Point Theorem, the existence criteria of three positive solutions are established